When to take it
With food, once or twice a day.
← All supplements
OtherModerate evidence
Trimethylglycine
Also known as: TMG, betaine
Trimethylglycine (betaine) is found in beetroot, spinach and whole grains and acts as a methyl donor in the body. It helps convert homocysteine into methionine.
What it is used for
- Normal homocysteine metabolism (EFSA-authorised claim at 1.5 g/day) – strong evidence
- Sports performance and body composition – weak evidence
- Liver support – weak evidence
Forms and how they differ
betaine anhydrous (TMG)
food supplement as powder or capsules
betaine HCl
a different product – used to support stomach acid, not homocysteine
Pairs well with
Works well with folate, vitamin B12 and B6.
Do not combine / separate
Do not confuse with betaine HCl. Be careful if your LDL is high – higher doses can raise it slightly.
Watch out for
In pregnancy and breastfeeding only after consulting your doctor. If you have kidney or liver disease, high cholesterol or take medicines, consult your doctor.
Safety
Well tolerated at usual doses; higher doses may cause digestive upset. Do not exceed the label dose.
Practical tip
It makes most sense when you have a measured high homocysteine – recheck it after a few months.
Products containing Trimethylglycine 4
B complex + Trimethylglycineactive forms
Trimethylglycine 1000 mgtrimethylglycine · 1 000 mg / tablet
Trimethylglycinetrimethylglycine
Trimethylglycine trimethylglycine (betaine anhydrous) 1800 mgtrimethylglycine (betaine anhydrous) · 1 800 mg / serving
How to read the evidence rating
Strong evidenceModerate evidenceWeak evidenceNo evidence
Strong = several good human studies or official recommendations; moderate = promising but smaller studies; weak = few studies or mixed results; no evidence = claims not confirmed.
Combination check
Select the supplements you take and, if relevant, your medicines. We show what interferes, what needs a time gap and what to watch out for.
Check Trimethylglycine with othersWhich supplements do you actually need?
Fénix Methode picks them from your blood results and schedules when to take what – no needless purchases.
From the same group
AlfalfaNo evidenceAndrographisWeak evidenceAroniaWeak evidenceBarley grassWeak evidenceBee pollenWeak evidenceBeef organs (desiccated)Weak evidence
Important notice
This information is educational and does not replace advice from a doctor or pharmacist. We do not give medicine dosages. Supplements are no substitute for a varied diet; if pregnant, breastfeeding, ill or on medication, consult a doctor first.