Evidence-based

Oestrogen, xenoestrogens and silent feminisation

Oestrogen is not just a female hormone. In men, it governs bone health, the cardiovascular system and libido. And today, the environment mimics it — without your knowledge.

MBMichal Bajus 2 min read Updated Book · chapter 5

How to read the numbers: Risk = what to watch out for · Fact = a finding from research or biology

Oestradiol (E2) is the main active form of oestrogen in both men and women. In men, it is produced by aromatisation of testosterone — via the enzyme aromatase, found in fat tissue, the liver and the brain. The optimal E2 level for men is 70–110 pmol/L. Below that range, osteoporosis and cardiovascular problems become a risk. Above it — gynaecomastia, water retention, low libido and depression.

Xenoestrogens

Xenoestrogens are chemicals that mimic oestrogen in the body. They are found in plastics (BPA, BPS, phthalates), pesticides, cosmetics (parabens), food preservatives and industrially farmed meat. When they bind to oestrogen receptors, the body cannot tell them apart from natural oestrogen.

Oestrogen in men — why it matters

Oestradiol protects the cardiovascular system — men with very low E2 have a higher risk of heart attack. It maintains bone density. It regulates libido — when E2 is too low, sexual desire drops just as it does with low testosterone. It affects mood and cognitive function. That is why "the less oestrogen, the better" is a misconception for men.

Xenoestrogens — an environmental assault

BPA (bisphenol A) from plastic bottles, containers and till receipts binds to oestrogen receptors. Phthalates from cosmetics, perfumes and plastic packaging suppress testosterone production. The pesticide atrazine (used on cereal crops) alters sex hormones in amphibians — and equivalent effects are observed in humans. Soy contains phytoestrogens (isoflavones) — harmless in small amounts, problematic with chronically high intake.

Symptoms of oestrogen dominance

In men: gynaecomastia (breast enlargement), water retention, visceral obesity, low libido, erectile dysfunction, fatigue, emotional instability. In women: PMS, fibroids, endometriosis, mastodynia, irregular cycles, weight gain on the hips and thighs.

Testing: Serum oestradiol (E2) — optimal for men 70–110 pmol/L; for women it depends on the phase of the cycle. The testosterone/E2 ratio is clinically more informative than the absolute E2 value.

Oestrogen detoxification — the protocol

DIM (diindolylmethane) from broccoli and cabbage steers oestrogen metabolism towards less active metabolites (2-hydroxyestrones vs. 16α-hydroxyestrones). Dose: 100–200 mg. I3C (indole-3-carbinol) — the precursor of DIM. Zinc inhibits aromatase. Eliminate plastics when eating and drinking (use glass and stainless steel). Resveratrol and quercetin block aromatase activity. Support liver detoxification: NAC, glutathione, curcumin.

Sources

6

Scientific studies, reviews and guidelines this article is based on.

  1. 1
  2. 2
    Estrogens as regulators of bone health in men Nature Reviews Endocrinology · 2009 Review
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  5. 5
    Bisphenol A in food is a health risk European Food Safety Authority (EFSA) · 2023 Official source
  6. 6

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AuthorMichal Bajus

Author of the book NAVRHNUTÝ and the Fénix Methode. He turns biohacking into clear steps based on your results, not on the average.

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This content is for information only and does not replace professional medical care. Consult your doctor before changing treatment, taking supplements or making major lifestyle changes.

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