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OtherWeak evidence

Milk thistle

Also known as: silymarin, Silybum marianum

Milk thistle contains silymarin, a mixture of flavonolignans with antioxidant properties. It is the best-known liver herb, but clinical trial results are inconsistent.

What it is used for

  • Liver support under strain – weak and inconsistent evidence
  • Antioxidant protection – mainly laboratory evidence
  • Treatment of liver disease – does not replace medical care

Forms and how they differ

standardised extract (silymarin)

the most common form, silymarin content usually stated

silybin with phospholipids

better-absorbed form

crushed seed

for tea or food, low concentration

When to take it

With meals, split through the day.

Pairs well with

Less alcohol, a healthy weight and exercise.

Do not combine / separate

Relying on the supplement instead of cutting down on alcohol.

Watch out for

If you are allergic to the daisy family, pregnant or breastfeeding, consult your doctor. It may affect some medicines, and with liver disease use it only after consulting your doctor.

Safety

Do not exceed the dose stated on the label.

Practical tip

The biggest benefit for your liver comes from less alcohol and sugar – the supplement is only an add-on.

Products containing Milk thistle 9

Berberine + Bitter melon + Milk thistleblendBlood sugar & metabolismHeart & vesselsWeight & satietyDigestion & gut
Milk thistle + Artichoke + Dandelion 300 mgsilymarin extract · 300 mg / capsuleLiverAntioxidantDigestion & gutHeart & vessels
Milk thistle + Liver support complexextractLiverAntioxidant
Milk thistleseed powderLiverAntioxidant
Milk thistle silymarin extract 150 mgsilymarin extract · 150 mg / capsuleLiverAntioxidant
Milk thistletinctureLiverAntioxidant
Milk thistlealcohol-free extractLiverAntioxidant
Milk thistle 450 mgsilymarin extract · 450 mg / capsuleLiverAntioxidant
Milk thistlesilybin phytosomeLiverAntioxidant
How to read the evidence rating
Strong evidenceModerate evidenceWeak evidenceNo evidence

Strong = several good human studies or official recommendations; moderate = promising but smaller studies; weak = few studies or mixed results; no evidence = claims not confirmed.

Combination check

Select the supplements you take and, if relevant, your medicines. We show what interferes, what needs a time gap and what to watch out for.

Check Milk thistle with others

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Important notice

This information is educational and does not replace advice from a doctor or pharmacist. We do not give medicine dosages. Supplements are no substitute for a varied diet; if pregnant, breastfeeding, ill or on medication, consult a doctor first.