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VitaminsModerate evidence

Vitamin B3

Also known as: niacin, nicotinamide

Vitamin B3 is part of the coenzymes NAD and NADP, which are essential for energy production and DNA repair. It exists as nicotinic acid, which causes flushing, and nicotinamide, which does not.

What it is used for

  • Normal energy metabolism, skin and nervous system – strong evidence (EFSA)
  • Nicotinamide to reduce risk of some non-melanoma skin cancers in high-risk people – moderate evidence, under dermatologist supervision
  • Improving blood lipids – nicotinic acid changes them, but large trials showed no fewer heart events; only under medical supervision

Forms and how they differ

nicotinamide (niacinamide)

no flushing, the most common supplement form

nicotinic acid

causes flushing and skin redness

inositol hexanicotinate (flush-free)

no flushing but releases little active niacin – weak evidence

When to take it

With food.

Pairs well with

Other B vitamins.

Do not combine / separate

Do not combine high doses with alcohol or medicines that burden the liver.

Watch out for

High doses can strain the liver and raise blood sugar and uric acid. With liver disease, diabetes, gout, stomach ulcers, in pregnancy and if you take medicines (e.g. statins), consult your doctor.

Safety

EFSA upper limits: 10 mg/day for nicotinic acid and 900 mg/day for nicotinamide.

Practical tip

Check which form your product contains – the difference between nicotinamide and nicotinic acid matters a lot.

Products containing Vitamin B3 7

Vitamin B3 250 mginositol hexanicotinate · 250 mg / capsuleEnergySkinLongevity
Vitamin B3 500 mginositol hexanicotinate · 500 mg / capsuleEnergySkinLongevity
Vitamin B3 inositol hexanicotinate 3 mginositol hexanicotinate · 3 mg / capsuleEnergySkinLongevity
Vitamin B3 500 mgnicotinic acid · 500 mg / tabletEnergySkinLongevity
Vitamin B3 1000 mgniacinamide · 1 000 mg / tabletEnergySkinLongevity
Vitamin B3 500 mgniacinamide (nicotinamide) · 500 mg / capsuleEnergySkinLongevity
Vitamin B3 nicotinamide 500 mgnicotinamide · 500 mg / capsuleEnergySkinLongevity
How to read the evidence rating
Strong evidenceModerate evidenceWeak evidenceNo evidence

Strong = several good human studies or official recommendations; moderate = promising but smaller studies; weak = few studies or mixed results; no evidence = claims not confirmed.

Combination check

Select the supplements you take and, if relevant, your medicines. We show what interferes, what needs a time gap and what to watch out for.

Check Vitamin B3 with others

Which supplements do you actually need?

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Important notice

This information is educational and does not replace advice from a doctor or pharmacist. We do not give medicine dosages. Supplements are no substitute for a varied diet; if pregnant, breastfeeding, ill or on medication, consult a doctor first.