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Amino acidsNo evidence

L-proline

Also known as: proline

Proline is a non-essential amino acid that, with glycine, makes up a large share of collagen. The body makes it on its own.

What it is used for

  • Collagen support for skin and joints – no reliable evidence for proline alone
  • Wound healing support – weak evidence, mainly in combinations

Forms and how they differ

L-proline

standard form in capsules and powder

When to take it

With food, optionally with vitamin C.

Pairs well with

Vitamin C, glycine, collagen.

Do not combine / separate

No need to add it to collagen, which already contains proline.

Watch out for

Consult your doctor or pharmacist if you are pregnant, breastfeeding, have kidney or liver disease or take any medicines.

Safety

Do not exceed the label dose.

Practical tip

For collagen goals, hydrolysed collagen is better researched than proline alone.

Products containing L-proline 2

L-proline free form 1000 mgfree form · 1 000 mg / servingSkinJoints
L-proline 500 mg500 mg / capsuleSkinJoints
How to read the evidence rating
Strong evidenceModerate evidenceWeak evidenceNo evidence

Strong = several good human studies or official recommendations; moderate = promising but smaller studies; weak = few studies or mixed results; no evidence = claims not confirmed.

Combination check

Select the supplements you take and, if relevant, your medicines. We show what interferes, what needs a time gap and what to watch out for.

Check L-proline with others

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Important notice

This information is educational and does not replace advice from a doctor or pharmacist. We do not give medicine dosages. Supplements are no substitute for a varied diet; if pregnant, breastfeeding, ill or on medication, consult a doctor first.