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Amino acidsWeak evidence

BCAA

Also known as: branched-chain amino acids (leucine, isoleucine, valine)

BCAAs are three essential amino acids – leucine, isoleucine and valine – of which leucine triggers muscle protein synthesis. With enough protein from food or protein powder, however, standalone BCAAs add little or no extra benefit.

What it is used for

  • Reduced muscle soreness after training – weak to moderate evidence
  • Muscle growth when protein intake is adequate – weak evidence; complete protein works better
  • Less fatigue during endurance exercise – weak evidence

Forms and how they differ

2:1:1 ratio

leucine, isoleucine and valine ratio similar to food protein

4:1:1 and higher

more leucine; advantage over 2:1:1 is not clearly shown

instant powder

water-soluble, often with sweeteners and flavours

tablets, combinations with electrolytes or L-lysine

convenient but many tablets per dose; composition depends on the label

When to take it

Before, during or after training; most useful when training fasted.

Pairs well with

Carbohydrates and electrolytes during endurance exercise.

Do not combine / separate

Do not use them to replace complete protein in your diet.

Watch out for

Do not use with the rare BCAA metabolism disorder (maple syrup urine disease). Take care with kidney or liver disease, in pregnancy and if you take diabetes medicines – consult your doctor.

Safety

Do not exceed the label dose.

Practical tip

If you eat enough protein daily (about 1.6 g per kg body weight for strength training), BCAAs are usually not worth the money.

Products containing BCAA 6

BCAA 2:1:1 + L-lysine HCl 8000 mg2:1:1 + L-lysine HCl · 8 000 mg / servingMusclesRecoveryEndurance
BCAAleucine:isoleucine:valine 2:1:1MusclesRecoveryEndurance
BCAA 2:1:1 1000 mg2:1:1 · 1 000 mg / servingMusclesRecoveryEndurance
BCAA 4:1:1 leucine:isoleucine:valine 4500 mg4:1:1 leucine:isoleucine:valine · 4 500 mg / servingMusclesRecoveryEndurance
BCAA 4:1:1 instant 6000 mg4:1:1 instant · 6 000 mg / servingMusclesRecoveryEndurance
BCAA 4:1:1 + electrolytes + CoQ10 5000 mg4:1:1 + electrolytes + CoQ10 · 5 000 mg / servingMusclesRecoveryEndurance
How to read the evidence rating
Strong evidenceModerate evidenceWeak evidenceNo evidence

Strong = several good human studies or official recommendations; moderate = promising but smaller studies; weak = few studies or mixed results; no evidence = claims not confirmed.

Combination check

Select the supplements you take and, if relevant, your medicines. We show what interferes, what needs a time gap and what to watch out for.

Check BCAA with others

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Important notice

This information is educational and does not replace advice from a doctor or pharmacist. We do not give medicine dosages. Supplements are no substitute for a varied diet; if pregnant, breastfeeding, ill or on medication, consult a doctor first.