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OtherWeak evidence

Indole-3-carbinol

Also known as: I3C, broccoli extract

Indole-3-carbinol is formed from glucosinolates in cruciferous vegetables such as broccoli and cabbage and is converted in the stomach into DIM and other compounds. It is studied for its effect on estrogen metabolism in the liver.

What it is used for

  • Support of estrogen metabolism – weak evidence, mainly laboratory and small studies
  • Protective effects of cruciferous vegetables – evidence concerns diet, not the supplement

Forms and how they differ

indole-3-carbinol (I3C)

unstable, converts in the stomach

DIM (diindolylmethane)

more stable metabolite, often sold separately

broccoli extract / sulforaphane

related but different compound

When to take it

With a meal.

Pairs well with

A varied diet with cruciferous vegetables.

Do not combine / separate

Combining with hormonal treatment without asking your doctor.

Watch out for

Not suitable in pregnancy or breastfeeding. If you have a hormone-sensitive condition, use hormonal contraception or therapy, or take medicines metabolised by the liver, consult your doctor.

Safety

Do not exceed the dose stated on the label.

Practical tip

The cheapest source is broccoli, cauliflower and cabbage on your plate.

Products containing Indole-3-carbinol 3

Indole-3-carbinolbroccoli extractHormonesLiverWomen’s health
Indole-3-carbinol broccoli extractbroccoli extractHormonesLiverWomen’s health
Indole-3-carbinol 200 mgI3C · 200 mg / capsuleHormonesLiverWomen’s health
How to read the evidence rating
Strong evidenceModerate evidenceWeak evidenceNo evidence

Strong = several good human studies or official recommendations; moderate = promising but smaller studies; weak = few studies or mixed results; no evidence = claims not confirmed.

Combination check

Select the supplements you take and, if relevant, your medicines. We show what interferes, what needs a time gap and what to watch out for.

Check Indole-3-carbinol with others

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From the same group

AlfalfaNo evidenceAndrographisWeak evidenceAroniaWeak evidenceBarley grassWeak evidenceBee pollenWeak evidenceBeef organs (desiccated)Weak evidence
Important notice

This information is educational and does not replace advice from a doctor or pharmacist. We do not give medicine dosages. Supplements are no substitute for a varied diet; if pregnant, breastfeeding, ill or on medication, consult a doctor first.