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VitaminsWeak evidence

Vitamin K2

Also known as: menaquinone, MK-7

Vitamin K2 activates proteins that bind calcium into bone and take part in blood clotting. It is found in fermented foods (natto, cheese); the long-acting MK-7 form stays in the blood longer than K1.

What it is used for

  • Maintenance of normal bones and blood clotting – strong evidence for the role of vitamin K (EFSA)
  • Lower fracture risk – weak to moderate, inconsistent evidence
  • Slowing vascular calcification – weak evidence

Forms and how they differ

MK-7

long half-life, once daily is enough; most common supplement form

MK-4

short half-life, studies used high doses

K2 with D3

common combination; check the vitamin D dose on the label

form not stated

the manufacturer should state whether it is MK-7 or MK-4

When to take it

With a meal containing fat, can be taken together with vitamin D.

Pairs well with

Vitamin D3, calcium, magnesium.

Do not combine / separate

Do not combine with warfarin-type medicines without consulting your doctor.

Watch out for

If you take warfarin-type blood thinners (vitamin K antagonists), vitamin K changes their effect – use it only after agreeing with your doctor. With other blood thinners, in pregnancy and with liver disease also consult your doctor.

Safety

EFSA has not set an upper limit; do not exceed the label dose.

Practical tip

If you take vitamin D above 2000 IU, adding K2 is a reasonable choice – though not yet backed by clear evidence.

Products containing Vitamin K2 24

Calcium + Vitamin D3 + Vitamin K2citrate + MK-7BonesMusclesElectrolytesImmunity
Calcium + Vitamin D3 + Vitamin K2 + Boronmicrocrystalline hydroxyapatiteBonesMusclesElectrolytesImmunity
Vitamin D3 + Vitamin K2 + Vitamin K1veganBonesImmunityMusclesMood
Vitamin D3 + Vitamin K2 5000 IUliquid · 5 000 IU / servingBonesImmunityMusclesMood
Vitamin D3 + Vitamin K2liposomalBonesImmunityMusclesMood
Vitamin D3 + Vitamin K2nanoemulsionBonesImmunityMusclesMood
Vitamin D3 + Vitamin K2cholecalciferol + MK-7BonesImmunityMusclesMood
Vitamin D3 + Vitamin K2 500 IUcholecalciferol + MK-7 in oil · 500 IU / servingBonesImmunityMusclesMood
Vitamin D3 + Vitamin K2cholecalciferol + MK-7BonesImmunityMusclesMood
Vitamin D3 + Vitamin K2 1000 IUcholecalciferol + MK-7 · 1 000 IU / capsuleBonesImmunityMusclesMood
Vitamin D3 + Vitamin K2 4000 IUcholecalciferol + all-trans MK-7 · 4 000 IU / capsuleBonesImmunityMusclesMood
Vitamin D3 + Vitamin K2 4000 IUlichen D3 + all-trans MK-7 · 4 000 IU / capsuleBonesImmunityMusclesMood
Vitamin D3 + Vitamin K2 5000 IUcholecalciferol + MK-7 · 5 000 IU / capsuleBonesImmunityMusclesMood
Vitamin K1 + Vitamin K2phylloquinone + MK-4 + MK-7Blood formationBonesHeart & vessels
Vitamin K2 + D3 120 µg+ D3 · 120 µg / servingBonesHeart & vessels
Vitamin K2MK-7 liquidBonesHeart & vessels
Vitamin K2 100 µgmenaquinone-4 · 100 µg / capsuleBonesHeart & vessels
Vitamin K2 menaquinone-7 100 µgmenaquinone-7 · 100 µg / servingBonesHeart & vessels
Vitamin K2 MK-7 100 µgMK-7 · 100 µg / servingBonesHeart & vessels
Vitamin K2 150 µgall-trans menaquinone-7 · 150 µg / capsuleBonesHeart & vessels
Vitamin K2 300 µgmenaquinone-7 · 300 µg / capsuleBonesHeart & vessels
Vitamin K2 45 µgmenaquinone-7 · 45 µg / capsuleBonesHeart & vessels
Vitamin K2 90 µgmenaquinone-7 · 90 µg / capsuleBonesHeart & vessels
Vitamin A + Vitamin D3 + Vitamin E + Vitamin K2fat-soluble complexEyesImmunitySkinBones
How to read the evidence rating
Strong evidenceModerate evidenceWeak evidenceNo evidence

Strong = several good human studies or official recommendations; moderate = promising but smaller studies; weak = few studies or mixed results; no evidence = claims not confirmed.

Combination check

Select the supplements you take and, if relevant, your medicines. We show what interferes, what needs a time gap and what to watch out for.

Check Vitamin K2 with others

Which supplements do you actually need?

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From the same group

B complexModerate evidenceBeta-caroteneWeak evidenceBiotinWeak evidenceBrewer's yeastWeak evidenceCamu camuWeak evidenceCholineModerate evidence
Important notice

This information is educational and does not replace advice from a doctor or pharmacist. We do not give medicine dosages. Supplements are no substitute for a varied diet; if pregnant, breastfeeding, ill or on medication, consult a doctor first.