When to take it
With a meal, ideally in the morning or at lunch.
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LongevityWeak evidence
Sulforaphane
Also known as: broccoli extract, broccoli sprout extract
Sulforaphane is a sulphur compound formed from glucoraphanin in broccoli and its sprouts by the enzyme myrosinase. It is studied as an activator of the Nrf2 pathway, which switches on the cells' own antioxidant and detoxification defences.
What it is used for
- activation of the body's own antioxidant defences – weak evidence in humans, mostly lab and small studies
- support of liver detoxification enzymes – weak evidence
- metabolic and inflammatory markers – preliminary, mixed results
Forms and how they differ
glucoraphanin + myrosinase
more stable form; sulforaphane forms in the body only if the enzyme is active
stabilised sulforaphane
direct form, usually more expensive
broccoli sprout powder
active content varies widely, check the label
Pairs well with
A diet rich in cruciferous vegetables; mustard seed (a source of myrosinase).
Do not combine / separate
No need to combine with high doses of other concentrated cruciferous extracts.
Watch out for
With thyroid disease or iodine deficiency be careful with high doses. During pregnancy or breastfeeding, with kidney or liver disease, or when taking medicines, consult your doctor.
Safety
Generally well tolerated; may cause bloating or wind. Do not exceed the label dose.
Practical tip
The cheapest source is fresh broccoli sprouts – chop them and let them stand a few minutes before eating.
Products containing Sulforaphane 1
Sulforaphanebroccoli seed extract
How to read the evidence rating
Strong evidenceModerate evidenceWeak evidenceNo evidence
Strong = several good human studies or official recommendations; moderate = promising but smaller studies; weak = few studies or mixed results; no evidence = claims not confirmed.
Combination check
Select the supplements you take and, if relevant, your medicines. We show what interferes, what needs a time gap and what to watch out for.
Check Sulforaphane with othersWhich supplements do you actually need?
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From the same group
Agaricus blazeiWeak evidenceAlpha-lipoic acidModerate evidenceAstaxanthinWeak evidenceCoenzyme Q10Moderate evidenceDNA protection blendNo evidenceErgothioneineWeak evidence
Important notice
This information is educational and does not replace advice from a doctor or pharmacist. We do not give medicine dosages. Supplements are no substitute for a varied diet; if pregnant, breastfeeding, ill or on medication, consult a doctor first.