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Amino acidsModerate evidence

NAC – N-acetylcysteine

Also known as: N-acetyl-L-cysteine

NAC is a more stable form of the amino acid cysteine that the body uses to make glutathione, the main intracellular antioxidant. Medically it is used to loosen mucus and in paracetamol poisoning.

What it is used for

  • Raising glutathione and antioxidant support – moderate evidence
  • Loosening thick mucus in cough – moderate evidence (medicinal use)
  • Liver support outside hospital treatment – weak evidence
  • Adjunct support in some mental health conditions – weak evidence

Forms and how they differ

NAC capsules

common supplement form, characteristic sulphur smell

effervescent tablets and sachets

often sold in pharmacies as a mucus medicine

When to take it

With or between meals; with food if your stomach is sensitive.

Pairs well with

Glycine (together they support glutathione), vitamin C.

Do not combine / separate

Do not combine with activated charcoal. Do not take at the same time as cough suppressants.

Watch out for

Caution with asthma, peptic ulcers, blood thinners and nitrates (nitroglycerin). Consult your doctor or pharmacist if you are pregnant, breastfeeding, have kidney or liver disease or take any medicines.

Safety

Do not exceed the label dose.

Practical tip

The sulphur smell is normal for NAC – keep capsules tightly closed in a dry place.

Products containing NAC – N-acetylcysteine 3

NAC – N-acetylcysteine N-acetyl-L-cysteine 150 mgN-acetyl-L-cysteine · 150 mg / capsuleAntioxidantLiverImmunity
NAC – N-acetylcysteine 600 mgNAC · 600 mg / capsuleAntioxidantLiverImmunity
NAC – N-acetylcysteine + Selenium + MolybdenumNACAntioxidantLiverImmunityThyroid
How to read the evidence rating
Strong evidenceModerate evidenceWeak evidenceNo evidence

Strong = several good human studies or official recommendations; moderate = promising but smaller studies; weak = few studies or mixed results; no evidence = claims not confirmed.

Combination check

Select the supplements you take and, if relevant, your medicines. We show what interferes, what needs a time gap and what to watch out for.

Check NAC – N-acetylcysteine with others

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Important notice

This information is educational and does not replace advice from a doctor or pharmacist. We do not give medicine dosages. Supplements are no substitute for a varied diet; if pregnant, breastfeeding, ill or on medication, consult a doctor first.