Magnesium is a mineral involved in more than 300 enzyme reactions, including energy production and muscle and nerve function. Low intake is common with diets low in vegetables, legumes and nuts, and under stress or heavy training.
What it is used for
Normal muscle and nervous system function – strong evidence (EFSA-approved claims)
Reduction of tiredness and fatigue – strong evidence when intake is low (EFSA)
Leg cramps – mixed, rather weak evidence, mainly helpful when deficient
Migraine prevention – moderate evidence
Forms and how they differ
bisglycinate
well tolerated, gentle on the stomach, good for evenings
citrate
well absorbed, may loosen stools at higher doses
oxide
cheap and high in elemental magnesium, but less well absorbed
malate, taurate, L-threonate
specialised forms; evidence for specific advantages is limited
When to take it
Any time of day with food; if you take it for sleep and relaxation, prefer the evening.
Pairs well with
Vitamin B6, vitamin D, potassium.
Do not combine / separate
Keep at least 2 hours apart from iron, high-dose zinc, some antibiotics (tetracyclines, quinolones), bisphosphonates and thyroid medication.
Watch out for
Take care with kidney disease – magnesium can accumulate. If you take medicines (especially antibiotics, thyroid, osteoporosis or blood pressure drugs), consult your doctor or pharmacist. In pregnancy use only after agreeing with your doctor.
Safety
EFSA set an upper limit of 250 mg/day of magnesium from supplements (not counting food). Diarrhoea is usually the first sign of too much.
Practical tip
If citrate loosens your stools, switch to bisglycinate or split the dose into two portions.
Strong = several good human studies or official recommendations; moderate = promising but smaller studies; weak = few studies or mixed results; no evidence = claims not confirmed.
Combination check
Select the supplements you take and, if relevant, your medicines. We show what interferes, what needs a time gap and what to watch out for.
This information is educational and does not replace advice from a doctor or pharmacist. We do not give medicine dosages. Supplements are no substitute for a varied diet; if pregnant, breastfeeding, ill or on medication, consult a doctor first.
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