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LongevityWeak evidence

Urolithin A

Also known as: UA

Urolithin A is produced in the gut when bacteria process ellagitannins from pomegranate, nuts or strawberries; however, not everyone produces enough of it. It is studied for effects on mitochondrial renewal (mitophagy) and muscle function, but human evidence is still limited.

What it is used for

  • muscle endurance and function in older adults – weak evidence from a few small studies
  • improved markers of mitochondrial health – weak evidence, short-term studies
  • lifespan extension – evidence only from animals and lab studies

Forms and how they differ

pure urolithin A capsules

the most studied form

powder

dose with the scoop as on the label

pomegranate extract

cheaper, but urolithin A production from it depends on your gut bacteria

When to take it

With food, once daily; judge any effect after several months.

Pairs well with

Regular exercise and strength training, enough protein.

Do not combine / separate

No significant interactions are known, though data are limited.

Watch out for

Safety data in pregnancy and breastfeeding are lacking. If you have liver or kidney disease, cancer, or take medicines, consult your doctor.

Safety

Well tolerated in short-term studies; long-term safety is unknown – do not exceed the label dose.

Practical tip

Urolithin A does not replace exercise – that remains the strongest known stimulus for healthy mitochondria.

Products containing Urolithin A 2

Urolithin Aurolithin ALongevityMusclesEndurance
Urolithin ApowderLongevityMusclesEndurance
How to read the evidence rating
Strong evidenceModerate evidenceWeak evidenceNo evidence

Strong = several good human studies or official recommendations; moderate = promising but smaller studies; weak = few studies or mixed results; no evidence = claims not confirmed.

Combination check

Select the supplements you take and, if relevant, your medicines. We show what interferes, what needs a time gap and what to watch out for.

Check Urolithin A with others

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Important notice

This information is educational and does not replace advice from a doctor or pharmacist. We do not give medicine dosages. Supplements are no substitute for a varied diet; if pregnant, breastfeeding, ill or on medication, consult a doctor first.