Amino acidsModerate evidence

SAMe

Also known as: S-adenosylmethionine, ademetionine

SAMe is a compound the body makes from the amino acid methionine; it donates methyl groups for hundreds of reactions, including neurotransmitter production. In some countries it is also used as a medicine.

What it is used for

low mood and depressive symptoms – moderate evidence, mainly as an add-on to treatment under medical supervision
osteoarthritis joint pain – moderate evidence, effect similar to common pain relievers but slower onset
liver support in cholestasis – weak to moderate evidence, in medical use

Forms and how they differ

SAMe tosylate (disulfate tosylate)

stable form; choose enteric-coated tablets in blisters

SAMe butanedisulfonate

another stable form, equally sensitive to moisture

When to take it

In the morning on an empty stomach or as the label says; in the evening it may disturb sleep in some people.

Pairs well with

Folate, vitamin B12, vitamin B6.

Do not combine / separate

Do not combine with antidepressants, triptans, tramadol, St John's wort or 5-HTP without your doctor – risk of serotonin syndrome. Take care with Parkinson's medicines.

Watch out for

Not suitable with bipolar disorder (may trigger mania). In pregnancy, during psychiatric treatment or when taking medicines, consult your doctor; it is not a substitute for depression treatment.

Safety

May cause digestive upset, insomnia or restlessness; do not exceed the label dose.

Practical tip

SAMe is moisture-sensitive – keep tablets in the blister rather than in a pill organiser.

Products containing SAMe 1

SAMe 200 mgtosylate · 200 mg / capsuleMoodJointsLiver

How to read the evidence rating

Strong evidenceModerate evidenceWeak evidenceNo evidence

Strong = several good human studies or official recommendations; moderate = promising but smaller studies; weak = few studies or mixed results; no evidence = claims not confirmed.

Combination check

Select the supplements you take and, if relevant, your medicines. We show what interferes, what needs a time gap and what to watch out for.

Check SAMe with others

Which supplements do you actually need?

Fénix Methode picks them from your blood results and schedules when to take what – no needless purchases.

Learn about Fénix Methode

From the same group

Acetyl-L-carnitineWeak evidence Almond proteinWeak evidence Amino acid complexWeak evidence BCAAWeak evidence Beef proteinModerate evidence CaseinStrong evidence

Important notice

This information is educational and does not replace advice from a doctor or pharmacist. We do not give medicine dosages. Supplements are no substitute for a varied diet; if pregnant, breastfeeding, ill or on medication, consult a doctor first.