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E635Caution

Disodium 5'-ribonucleotides

Group: Flavour enhancers

Harm level3 of 5In moderation

In plain words

Disodium 5'-ribonucleotides are a mix of guanylate and inosinate used as a strong flavour enhancer. You find them in crisps, instant noodles, stock cubes and savoury snacks, often with MSG.

Where you find it: instant soups, crisps, stock cubes, seasoning mixes

Our recommendation

We recommend limiting it; people with gout or high uric acid should avoid it.

Possible risks and effects

  • Contains purines that turn into uric acid – unsuitable with gout and high uric acid.
  • Usually combined with MSG, boosting the overall umami effect.
  • May be of animal origin (e.g. fish), relevant for vegans.

For experts

A mixture of the sodium salts of guanosine and inosine monophosphate (E627 and E631), obtained from yeast, by fermentation or from animal sources. It acts strongly in synergy with glutamate, so very small amounts suffice; it is not considered toxic at normal use, the main limitation being its purine content.

Check another E-number

More from this group

E620Glutamic acidE621Monosodium glutamate (MSG)E622Monopotassium glutamateE627Disodium guanylateE631Disodium inosinateE640Glycine

This information is educational and based on EFSA assessments and available studies; it does not replace medical advice. With allergies, intolerances or illness, follow your doctor’s advice.