When to take it
In the morning or before training, not late in the afternoon.
← All supplements
PerformanceWeak evidence
Synephrine
Also known as: p-synephrine, bitter orange, Citrus aurantium
Synephrine is a stimulant from bitter orange peel, chemically related to ephedrine but with a weaker effect. It is added to fat burners and pre-workout blends to increase energy expenditure.
What it is used for
- Slight increase in energy expenditure – weak evidence
- Weight loss – weak evidence, the effect is small
Forms and how they differ
bitter orange extract (p-synephrine)
check the synephrine content per dose
fat burners with synephrine and caffeine
the combination increases stimulation, quality depends on the label
Pairs well with
If at all, on its own and without other stimulants.
Do not combine / separate
Do not combine with high doses of caffeine, other stimulants, blood-pressure medicines or antidepressants (especially MAO inhibitors).
Watch out for
Not suitable with high blood pressure, heart rhythm disorders, heart disease, anxiety, in pregnancy, while breastfeeding or for adolescents. With kidney or liver disease and when taking medicines, consult your doctor.
Safety
Do not exceed the label dose; stop if you get palpitations or a headache.
Practical tip
Before competing, check the current anti-doping rules of your sport.
Products containing Synephrine 1
Synephrine bitter orange extractbitter orange extract
How to read the evidence rating
Strong evidenceModerate evidenceWeak evidenceNo evidence
Strong = several good human studies or official recommendations; moderate = promising but smaller studies; weak = few studies or mixed results; no evidence = claims not confirmed.
Combination check
Select the supplements you take and, if relevant, your medicines. We show what interferes, what needs a time gap and what to watch out for.
Check Synephrine with othersWhich supplements do you actually need?
Fénix Methode picks them from your blood results and schedules when to take what – no needless purchases.
From the same group
AmylopectinModerate evidenceBeta-alanineStrong evidenceBHB ketonesWeak evidenceCaffeineStrong evidenceCreatineStrong evidenceD-aspartic acidWeak evidence
Important notice
This information is educational and does not replace advice from a doctor or pharmacist. We do not give medicine dosages. Supplements are no substitute for a varied diet; if pregnant, breastfeeding, ill or on medication, consult a doctor first.