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Amino acidsWeak evidence

L-ornithine

Also known as: ornithine

Ornithine is a non-essential amino acid of the urea cycle, which helps the body clear ammonia. It is often combined with arginine.

What it is used for

  • Reduced fatigue during prolonged exercise – weak evidence
  • Better sleep quality and less stress – weak evidence from small studies
  • Raising growth hormone – weak evidence, no proven effect on muscle

Forms and how they differ

L-ornithine HCl

standard form in capsules and powder

ornithine aspartate (LOLA)

used medically in liver disease

arginine combinations

often in one product, read the label

When to take it

Evening or after training.

Pairs well with

Arginine, citrulline.

Do not combine / separate

Avoid large single doses – they can cause digestive upset.

Watch out for

Consult your doctor or pharmacist if you are pregnant, breastfeeding, have kidney or liver disease or take any medicines.

Safety

Do not exceed the label dose.

Practical tip

Ornithine is not a muscle-building shortcut – for fatigue, look at sleep and diet first.

Products containing L-ornithine 4

L-arginine + L-citrulline + L-ornithinepowderHeart & vesselsEnduranceLibidoRecovery
L-ornithine 500 mg500 mg / capsuleRecoverySleepLiver
L-ornithine L-ornithine hydrochloride 500 mgL-ornithine hydrochloride · 500 mg / capsuleRecoverySleepLiver
L-ornithinefree formRecoverySleepLiver
How to read the evidence rating
Strong evidenceModerate evidenceWeak evidenceNo evidence

Strong = several good human studies or official recommendations; moderate = promising but smaller studies; weak = few studies or mixed results; no evidence = claims not confirmed.

Combination check

Select the supplements you take and, if relevant, your medicines. We show what interferes, what needs a time gap and what to watch out for.

Check L-ornithine with others

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Important notice

This information is educational and does not replace advice from a doctor or pharmacist. We do not give medicine dosages. Supplements are no substitute for a varied diet; if pregnant, breastfeeding, ill or on medication, consult a doctor first.