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DigestionModerate evidence

Saccharomyces boulardii

Also known as: probiotic yeast, S. boulardii

Saccharomyces boulardii is a probiotic yeast which, unlike bacteria, is not sensitive to antibiotics. It is one of the best-studied probiotics, especially for preventing antibiotic-associated diarrhoea.

What it is used for

  • preventing antibiotic-associated diarrhoea – moderate to strong evidence from meta-analyses
  • traveller's and acute diarrhoea – moderate evidence
  • add-on to H. pylori treatment (fewer side effects) – moderate evidence

Forms and how they differ

freeze-dried capsules

stable at room temperature; dose in billions of cells

sachets for children

contents can be mixed into a drink, not a hot one

combination with MOS (mannan-oligosaccharides)

a prebiotic addition – quality depends on the label

When to take it

During antibiotics and for 1–2 weeks after; it can be taken at the same time as the antibiotic.

Pairs well with

Probiotic bacteria (lactobacilli, bifidobacteria), fibre.

Do not combine / separate

Do not take together with antifungal medicines – they kill the yeast.

Watch out for

Not suitable with weakened immunity, a central venous catheter or in critically ill people – there is a rare risk of yeast bloodstream infection. During pregnancy or breastfeeding, with kidney or liver disease, or when taking medicines, consult your doctor.

Safety

Very safe in healthy people; occasional bloating. Do not exceed the label dose.

Practical tip

Do not stir the capsule contents into hot drinks – heat kills the yeast.

Products containing Saccharomyces boulardii 2

Saccharomyces boulardii + Prebiotic fibre 5 bn CFUyeast probiotic · 5 bn CFU / capsuleDigestion & gutImmunityBlood sugar & metabolismWeight & satiety
Saccharomyces boulardii 5 bn CFUyeast probiotic · 5 bn CFU / capsuleDigestion & gutImmunity
How to read the evidence rating
Strong evidenceModerate evidenceWeak evidenceNo evidence

Strong = several good human studies or official recommendations; moderate = promising but smaller studies; weak = few studies or mixed results; no evidence = claims not confirmed.

Combination check

Select the supplements you take and, if relevant, your medicines. We show what interferes, what needs a time gap and what to watch out for.

Check Saccharomyces boulardii with others

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From the same group

Acacia fibreWeak evidenceActivated charcoalModerate evidenceAloe veraWeak evidenceApple fibreModerate evidenceArtichokeWeak evidenceBetaine HClWeak evidence
Important notice

This information is educational and does not replace advice from a doctor or pharmacist. We do not give medicine dosages. Supplements are no substitute for a varied diet; if pregnant, breastfeeding, ill or on medication, consult a doctor first.