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Nattokinase

Also known as: natto enzyme

Nattokinase is an enzyme from natto, a traditional Japanese food made from fermented soybeans. It is studied for its ability to break down fibrin and support circulation, but human evidence is limited.

What it is used for

  • Circulation support and fibrin breakdown – weak evidence
  • Modest blood pressure reduction – weak evidence from small studies

Forms and how they differ

capsules with FU activity

enzyme activity is given in fibrinolytic units

natto

a food, also contains vitamin K2

When to take it

On an empty stomach or between meals.

Pairs well with

Exercise, a vegetable-rich diet.

Do not combine / separate

Combining with blood thinners and aspirin.

Watch out for

It increases bleeding risk – not suitable with blood thinners, aspirin, clotting disorders or before surgery without consulting your doctor. Not recommended in pregnancy, breastfeeding, low blood pressure or soy allergy.

Safety

Do not exceed the dose stated on the label.

Practical tip

Nattokinase does not replace heart and circulation medicines – if you take them, consult your doctor.

Products containing Nattokinase 1

Nattokinase enzymeenzymeHeart & vesselsBlood formation
How to read the evidence rating
Strong evidenceModerate evidenceWeak evidenceNo evidence

Strong = several good human studies or official recommendations; moderate = promising but smaller studies; weak = few studies or mixed results; no evidence = claims not confirmed.

Combination check

Select the supplements you take and, if relevant, your medicines. We show what interferes, what needs a time gap and what to watch out for.

Check Nattokinase with others

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Important notice

This information is educational and does not replace advice from a doctor or pharmacist. We do not give medicine dosages. Supplements are no substitute for a varied diet; if pregnant, breastfeeding, ill or on medication, consult a doctor first.