When to take it
With or between meals, as on the label.
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LongevityWeak evidence
Grape seed extract
Also known as: OPC, proanthocyanidins
Grape seed extract is rich in proanthocyanidins (OPC), polyphenols with antioxidant activity. It is studied mainly for blood pressure and venous insufficiency, where it may have a modest effect.
What it is used for
- modest blood pressure reduction – weak to moderate evidence from meta-analyses of smaller studies
- vein support for heavy legs – weak evidence
- antioxidant protection – weak evidence for clinical benefit
Forms and how they differ
extract standardised to OPC / proanthocyanidins
prefer products stating the percentage (e.g. 80–95%)
combinations with pine bark extract or vitamin C
similar polyphenols, effect depends on doses
Pairs well with
A diet rich in fruit and vegetables, exercise, less salt.
Do not combine / separate
Do not combine with blood thinners or blood-pressure medicines without asking your doctor; keep a gap from iron, as polyphenols may reduce its absorption.
Watch out for
If you take blood thinners, before surgery, during pregnancy and breastfeeding, or with liver or kidney disease, consult your doctor.
Safety
Usually well tolerated; do not exceed the label dose.
Practical tip
If you track blood pressure, measure it at home before starting and after 8 weeks – that is how you will see whether it helps.
Products containing Grape seed extract 2
Grape seed extract 100 mgOPC standardized · 100 mg / capsule
Grape seed extract 250 mgOPC standardized · 250 mg / capsule
How to read the evidence rating
Strong evidenceModerate evidenceWeak evidenceNo evidence
Strong = several good human studies or official recommendations; moderate = promising but smaller studies; weak = few studies or mixed results; no evidence = claims not confirmed.
Combination check
Select the supplements you take and, if relevant, your medicines. We show what interferes, what needs a time gap and what to watch out for.
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From the same group
Agaricus blazeiWeak evidenceAlpha-lipoic acidModerate evidenceAstaxanthinWeak evidenceCoenzyme Q10Moderate evidenceDNA protection blendNo evidenceErgothioneineWeak evidence
Important notice
This information is educational and does not replace advice from a doctor or pharmacist. We do not give medicine dosages. Supplements are no substitute for a varied diet; if pregnant, breastfeeding, ill or on medication, consult a doctor first.